Lithium Hydroxide → HCID 59771819, compound

HRID 2219899Notes

Reaction equation

HRID 2219899 reaction equation
[NH2:1][C:2](=[O:35])[C@H:3]([NH:24][S:25]([C:28]1[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=1)(=[O:27])=[O:26])[CH2:4][C:5]1[N:6]=[N:7][N:8]([C@@H:10]2[CH2:19][CH2:18][CH2:17][C:16]3[CH:15]=[C:14]([C:20]([O:22]C)=[O:21])[CH:13]=[CH:12][C:11]2=3)[CH:9]=1.[Li+].[OH-]>C1COCC1>[NH2:1][C:2](=[O:35])[C@H:3]([NH:24][S:25]([C:28]1[CH:29]=[CH:30][C:31]([CH3:34])=[CH:32][CH:33]=1)(=[O:27])=[O:26])[CH2:4][C:5]1[N:6]=[N:7][N:8]([C@@H:10]2[CH2:19][CH2:18][CH2:17][C:16]3[CH:15]=[C:14]([C:20]([OH:22])=[O:21])[CH:13]=[CH:12][C:11]2=3)[CH:9]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 59771807HCID 59771807, compound

Product 1

HCID 59771819HCID 59771819, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(R)-Methyl 5-(4-((R)-3-amino-2-(4-methylbenzenesulfonamido)-3-oxopropyl)-1H-1,2,3-triazol-1-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxylate (0.2 g, 0.41 mmol) and 1N LiOH (1.9 mL, 1.9 mmol) in 5 mL THF was stirred for 16 h at RT. The reaction mixture was concentrated, taken up in H2O, and acidified with 10% HCl. A precipitate had formed, that was filtered and air-dried to afford the title compound. MS (m/z): 484.4 (m+H).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customA precipitate had formed
  3. filtrationthat was filtered
  4. customair-dried

Sources & evidence

ORD record
ord-30549f72322e49d0b2f54c4ebb743f5e
Source dataset
uspto-grants-2008_08
Patent number
US07414134B2

Reaction notes

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