Morpholine → HCID 55289212, compound

HRID 2219925Notes

Reaction equation

HRID 2219925 reaction equation
[H-].[Na+].[NH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.Cl.Cl[CH2:11][C:12]([NH2:14])=[NH:13]>C1COCC1>[O:6]1[CH2:7][CH2:8][N:3]([CH2:11][CH:12]([NH2:14])[NH2:13])[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 24758Sodium hydrideHCID 27769572-Chloroacetamidine monohydrochloride

Product 1

HCID 55289212HCID 55289212, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Sodium hydride (2.4 g, 60 mmol, 60%) was added to the solution of morpholine (5.2 g, 60 mmol) in THF (40 mL, anhydrous) and stirred for 30 min at room temperature under nitrogen. Chloroacetamidine hydrochloride (2.58 g, 20 mmol) was added to this solution in one portion and stirred at 50° C. overnight. Solvent was removed under reduced pressure and the dark brown oily residue was directly used in the next step.

Workup

  1. stirringstirred at 50° C. overnight
  2. customSolvent was removed under reduced pressure

Sources & evidence

ORD record
ord-8ee66377854041598e30a0a8dcc2d1c4
Source dataset
uspto-grants-2008_08
Patent number
US07414131B2

Reaction notes

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