HCID 59021554, compound → HCID 59021465, compound

HRID 2219929Notes

Reaction equation

HRID 2219929 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:13]3[CH2:28][CH2:27][N:26](CC4C=CC=CC=4)[CH2:25][C:14]=3[N:15]=[C:16]([CH2:18][N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[N:17]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[OH-].[OH-].[Pd+2]>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:13]3[CH2:28][CH2:27][NH:26][CH2:25][C:14]=3[N:15]=[C:16]([CH2:18][N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[N:17]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 59021554HCID 59021554, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59021465HCID 59021465, compoundYield 77.1%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

Catalytic amount palladium hydroxide on carbon powder (20% Pd, moisture ea. 60%) was added to the solution of N-(4-tert-butylphenyl)-7-benzyl-5,6,7,8-tetrahydro-2-(morpholinomethyl)pyrido[3,4-d]pyrimidin-4-amine (240 mg, 0.51 mmol) in methanol and was stirred at hydrogen atmosphere over night at room temperature. Reaction solution was filtered through celite and filtrate was concentrated to yield the product as a white powder (150 mg, 77%).

Workup

  1. customReaction solution
  2. filtrationwas filtered through celite and filtrate
  3. concentrationwas concentrated

Sources & evidence

ORD record
ord-1dc9662d3d5241108720f3bdad5536ff
Source dataset
uspto-grants-2008_08
Patent number
US07414131B2

Reaction notes

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