Hydrochloric Acid → 1-Isobutyl-4-(3-methanesulfonyl-phenyl)-piperidine

HRID 2220082Notes

Reaction equation

HRID 2220082 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[CH2:17](Br)[CH:18]([CH3:20])[CH3:19].Cl>>[CH2:17]([N:14]1[CH2:15][CH2:16][CH:11]([C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH:6]=2)[CH2:12][CH2:13]1)[CH:18]([CH3:20])[CH3:19]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 65551-Bromo-2-methylpropaneHCID 129889574-(3-(Methylsulfonyl)phenyl)piperidine

Product 1

HCID 129889581-Isobutyl-4-(3-methanesulfonyl-phenyl)-piperidine

Procedure

Beginning with 4-(3-methanesulfonyl-phenyl)piperidine and i-butylbromide; m.p. 212° C. (HCl); MS m/z (rel. intensity, 70 eV) 295 (M+, 1), 252 (80), 129 (40), 115 (50), 70 (bp)

Sources & evidence

ORD record
ord-5786d23dc9b849f7b824105994ff659b
Source dataset
uspto-grants-2008_08
Patent number
US07417043B2

Reaction notes

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