HCID 68968184, compound → HCID 11660395, compound

HRID 2220218Notes

Reaction equation

HRID 2220218 reaction equation
[C:1]([N:4]1[CH2:11][C:10]2[CH:12]=[CH:13][C:14]([S:16]([CH2:18][CH2:19][CH2:20][CH3:21])=[O:17])=[CH:15][C:9]=2[CH:8]=[CH:7][C:6]2[CH:22]=[CH:23][CH:24]=[CH:25][C:5]1=2)(=[O:3])[CH3:2]>CO.[OH-].[OH-].[Pd+2]>[C:1]([N:4]1[CH2:11][C:10]2[CH:12]=[CH:13][C:14]([S:16]([CH2:18][CH2:19][CH2:20][CH3:21])=[O:17])=[CH:15][C:9]=2[CH2:8][CH2:7][C:6]2[CH:22]=[CH:23][CH:24]=[CH:25][C:5]1=2)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 68968184HCID 68968184, compound

Product 1

HCID 11660395HCID 11660395, compoundYield 37%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

To a solution of compound Example 287B (8 mg, 0.023 mmol) in MeOH (5 mL) was added Pd(OH)2/C (26 mg). The mixture was stirred at room temperature under a hydrogen atmosphere for 2 hours. The solution was filtered through a nylon membrane filter, concentrated and purified by preparative HPLC to give the title compound (3 mg, 37%). HPLC Rt=3.517 min. m/z=356(M+H+).

Workup

  1. filtrationThe solution was filtered through a nylon membrane
  2. filtrationfilter
  3. concentrationconcentrated
  4. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-4b344384143f44c894eb46545bce702f
Source dataset
uspto-grants-2008_08
Patent number
US07417040B2

Reaction notes

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