反应详情

To a solution of 3-(4-bromophenyl)propanoic acid (15.0 g) in thionyl chloride (24.5 g) was added catalytic amount of N,N-dimethylformamide (one drop) and refluxed for 1.5 hours under nitrogen atmosphere. After cooling to room temperature, the reaction mixture was poured slowly into 28% aqueous ammonium hydroxide solution (150 ml) at 0° C. The mixture was extracted with ethyl acetate, washed with water and brine and dried over magnesium sulfate. Filtration followed by evaporation under reduced pressure gave 3-(4-bromophenyl)propanamide (13.7 g) as a white solid.

1. temperaturerefluxed for 1.5 hours under nitrogen atmosphere
2. extractionThe mixture was extracted with ethyl acetate
3. washwashed with water and brine
4. dry with materialdried over magnesium sulfate
5. filtrationFiltration
6. customfollowed by evaporation under reduced pressure