1-Methylpiperazine → HCID 67311978, compound

HRID 222058Notes

Reaction equation

Br[CH2:2][CH2:3][N:4]1[C:8]2[CH2:9][CH2:10][C:11]3[C:12]4[C:17]([S:18][C:19]=3[C:7]=2[CH:6]=[N:5]1)=[N:16][CH:15]=[N:14][C:13]=4[O:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=1.[CH3:32][N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[CH3:32][N:33]1[CH2:38][CH2:37][N:36]([CH2:2][CH2:3][N:4]2[C:8]3[CH2:9][CH2:10][C:11]4[C:12]5[C:17]([S:18][C:19]=4[C:7]=3[CH:6]=[N:5]2)=[N:16][CH:15]=[N:14][C:13]=5[O:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=2)[CH2:35][CH2:34]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 58346788HCID 58346788, compound

Product 1

HCID 67311978HCID 67311978, compoundYield 100%

Procedure

This compound was prepared in a similar fashion as described in Example 48 step 6 starting from 3-(2-bromo-ethyl)-6-[2-(4-nitro-phenyl)-ethoxy]-4,5-dihydro-3H-10-thia-2,3,7,9-tetraaza-cyclopenta[a]fluorene (2.6 g, 5.2 mmol) and N-methyl piperazine (1.56 g, 15.59 mmol). The crude desired product was obtained as a light yellow solid (2.7 g) in 100% yield.

Workup

customThis compound was prepared in a similar fashion

Sources & evidence

ORD record: ord-46e3d3f5b94c4aebb56155f831cec944
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08207172B2

Reaction notes

Loading…