反应详情

A mixture of methyl 4-bromo-2-isopropylbenzoate (0.41 g) and lithium hydroxide monohydrate (0.669 g) in water (1 mL)/1,4-dioxane (3 mL) was stirred at room temperature for 5 days. To the reaction mixture was added 2 mol/L hydrochloric acid (10 mL), and the resulting mixture was extracted with ethyl acetate. The solvent was evaporated under reduced pressure, and the residue was recrystallized from ethyl acetate/n-hexane to afford the title compound (0.276 g).

1. extractionthe resulting mixture was extracted with ethyl acetate
2. customThe solvent was evaporated under reduced pressure
3. customthe residue was recrystallized from ethyl acetate/n-hexane