反应详情

Lithium hydroxide monohydrate (0.19 g) was added to a mixture of ethyl 4′-(2-hydroxyethoxy)-2-methylbiphenyl-4-carboxylate (0.136 g), ethanol (2 mL), 1,4-dioxane (2 mL) and water (1 mL), and the mixture was stirred at room temperature overnight. To the reaction mixture was added 2 mol/L hydrochloric acid (2.3 mL). The solvent was evaporated under reduced pressure, and water and ethyl acetate were added to the residue. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: ethylacetate/n-hexane=2/1-4/1) to afford the title compound (0.066 g).

1. customThe solvent was evaporated under reduced pressure, and water and ethyl acetate
2. additionwere added to the residue
3. customThe organic layer was separated
4. washwashed with water and brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customThe solvent was evaporated under reduced pressure
7. customthe residue was purified by silica gel column chromatography (eluent: ethylacetate/n-hexane=2/1-4/1)