2-(2-Aminoethyl)-1-methylpyrrolidine → HCID 59502240, compound

HRID 2220696Notes

Reaction equation

HRID 2220696 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH:11]=O.[CH3:13][N:14]1[CH2:18][CH2:17][CH2:16][CH:15]1[CH2:19][CH2:20][NH2:21].[Na]>ClCCl>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:11][NH:21][CH2:20][CH2:19][CH:15]1[CH2:16][CH2:17][CH2:18][N:14]1[CH3:13]

Participants

5

Reactant 3

HCID 983882-(2-Aminoethyl)-1-methylpyrrolidineHCID 7620841-methyl-1H-1,3-benzodiazole-2-carbaldehydeHCID 5360545Sodium

Product 1

HCID 59502240HCID 59502240, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Experimental condition analogous to Example 5, from 1-methyl-1H-benzoimidazol-2-carbaldehyde 0.2 g (1.25 mmol), 2-(1-methyl-pyrrolidin-2-yl)-ethylamine 0.18 g (1.38 mmol), and sodium triacethoxyborohydride 0.39 g (1.87 mmol), in 10 mL dichloromethane. After work-up the material was used as a crude.

Sources & evidence

ORD record
ord-1a58457db96345a8b58907a9d21d492b
Source dataset
uspto-grants-2008_08
Patent number
US07417062B2

Reaction notes

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