Methyl Acrylate → HCID 59773018, compound

HRID 2220698Notes

Reaction equation

HRID 2220698 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:14]([O:18][CH3:19])(=[O:17])[CH:15]=[CH2:16]>>[CH3:19][O:18][C:14](=[O:17])[CH2:15][CH2:16][NH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7294Methyl Acrylate2×HCID 167173-Aminobiphenyl

Product 1

HCID 59773018HCID 59773018, compoundYield 41%

Conditions

Temperature
90 °C

Procedure

In a round bottom flask was added 3-aminobiphenyl 2.6 g (15.3 mmol), methyl acrylate 1.5 g (16.9 mmol) and cupric acetate 0.1 g, the reaction mixture was stirred 5 hour at 90° C., another 5 equivalent of methyl acrylate 7 g (75 mmol), and 0.25 g of cupric acetate was added, and the reaction mixture was heated for another 5 hours. The crude was purified using silica gel chromatography using 15% of ethyl acetate and petroleum ether. Yield to 1.6 g of oil.

Workup

  1. temperaturethe reaction mixture was heated for another 5 hours
  2. customThe crude was purified

Sources & evidence

ORD record
ord-97154888819f4356afb24f2c5bbb096f
Source dataset
uspto-grants-2008_08
Patent number
US07417062B2

Reaction notes

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