Pyrazole → HCID 59773342, compound

HRID 2220768Notes

Reaction equation

N1C=[CH:4][CH:3]=N1.CC1CCCCC1NC([C:16]1[C:20](Br)=[C:19]([NH:22][C:23](=O)[C:24]2[CH:29]=[CH:28][CH:27]=CC=2Cl)N[N:17]=1)=O.[C:32](Cl)(=O)C.O=[C:37]1NC2C=CC=CC=2C(C2C=CC=CC=2)=N[CH:38]1[NH:54][C:55]([C:57]1[C:61](C)=[C:60]([NH:63][C:64](=[O:72])[C:65]2C=CC=CC=2Cl)[N:59]([C:73]2[CH:78]=[CH:77][CH:76]=[CH:75]N=2)[N:58]=1)=[O:56]>>[N:22]1([C:19]2[CH:20]=[CH:16][N:17]=[CH:4][CH:3]=2)[CH2:23][CH2:24][CH:29]([CH2:37][CH2:38][NH:54][C:55]([C:57]2[CH:61]=[C:60]([NH:63][C:64](=[O:72])[CH3:65])[N:59]([C:73]3[CH:78]=[CH:77][CH:76]=[CH:75][CH:32]=3)[N:58]=2)=[O:56])[CH2:28][CH2:27]1

Participants

Reactant 4

HCID 1048Pyrazole

HCID 6367Acetyl chloride

HCID 598122274-Methyl-5-(2-chloro-benzoylamino)-1-(pyridine-2-yl)-pyrazole-3-carboxylic acid(2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)amide

HCID 178424381HCID 178424381, compound

Product 1

HCID 59773342HCID 59773342, compound

Procedure

The pyrazole acid, prepared as described in Procedure 8 using compound 188 (Procedure 41) in place of compound 20 and acetyl chloride in place of compound 21, was coupled to 2-(3,4,5,6-tetrahydro-2H-[1,4′]bipyridin-4-yl)ethylamine (prepared as described in Procedure 14) using the method of Procedure 10.

Sources & evidence

ORD record: ord-7a33782ec3b64bee8fcb8511644061b1
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07417152B2

Reaction notes

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