HCID 69045866, compound → HCID 68708273, compound

HRID 222093Notes

Reaction equation

HRID 222093 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:17]2[CH2:16][CH2:15][C:14]3[C:10](=[CH:11][N:12](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:13]=3)[C:9]=2[N:8]([CH3:37])[C:7]=1C(OC(C)(C)C)=O)=[O:5])[CH3:2]>CCO.Cl>[CH2:1]([O:3][C:4]([C:6]1[C:17]2[CH2:16][CH2:15][C:14]3[NH:13][N:12]=[CH:11][C:10]=3[C:9]=2[N:8]([CH3:37])[CH:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 69045866HCID 69045866, compound

Product 1

HCID 68708273HCID 68708273, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a mixture of 1-methyl-7-trityl-1,4,5,7-tetrahydro-1,6,7-triaza-as -indacene-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester VI (2.4 mmol) in EtOH (60 mL), 2N HCl (6 mL) was added and the reaction was heated at 80° C. for 2 h. The solvent was evaporated and the residue was washed twice with DCM/hexane. The title product was obtained as a solid (98% yield). ESI (+) MS: m/z 246 (MH+). 1H NMR: 1.27 (t, 3H), 2.78 (t, 2H), 2.97 (dt, 2H), 3.74 (s, 3H), 4.18 (q, 2H), 7.32 (s, 1H), 7.82 (s, 1H).

Workup

  1. additionwas added
  2. customThe solvent was evaporated
  3. washthe residue was washed twice with DCM/hexane

Sources & evidence

ORD record
ord-643f5894b96a4a89ab4e5b5da2cde1b1
Source dataset
uspto-grants-2012_06
Patent number
US08207180B2

Reaction notes

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