Carbodiimide → HCID 60208253, compound

HRID 2221020Notes

Reaction equation

HRID 2221020 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][CH2:11][N:12]1[C:21](=[O:22])[C:20]2[C:15](=[CH:16][C:17]([NH:23][C:24]([NH:26][C@H:27]3[CH2:32][C@H:31]4[CH2:33][C@H:29]([C:30]4([CH3:35])[CH3:34])[C@@H:28]3[CH3:36])=S)=[CH:18][CH:19]=2)[N:14]=[CH:13]1.N=C=N>C1COCC1>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][CH2:11][N:12]1[C:21](=[O:22])[C:20]2[C:15](=[CH:16][C:17]([N:23]=[C:24]=[N:26][C@H:27]3[CH2:32][C@H:31]4[CH2:33][C@H:29]([C:30]4([CH3:35])[CH3:34])[C@@H:28]3[CH3:36])=[CH:18][CH:19]=2)[N:14]=[CH:13]1

Participants

4

Reactant 2

HCID 160435CarbodiimideHCID 60208254HCID 60208254, compound

Product 1

HCID 60208253HCID 60208253, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

N-(3-{2-[2-fluoro-4-(methyloxy)phenyl]ethyl}-4-oxo-3,4-dihydro-7-quinazolinyl)-N′-[(1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]thiourea was gently stirred with Argonaut PS-Carbodiimide (1.5 eq) for 15 hours in THF. The resin was filtered off and the solution of carbodiimide A was diluted to a known volume to give a solution of known molarity.

Workup

  1. filtrationThe resin was filtered off
  2. additionthe solution of carbodiimide A was diluted to a known volume
  3. customto give a solution of known molarity

Sources & evidence

ORD record
ord-d28bc2157cd14a008b56cfd5000ad163
Source dataset
uspto-grants-2008_05
Patent number
US07368453B2

Reaction notes

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