HCID 23369980, compound → [1,4'-Bipiperidin]-2-one

HRID 2221081Notes

Reaction equation

HRID 2221081 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][C:18]2=[O:23])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].C(O)C>[N:17]1([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH2:22][CH2:21][CH2:20][CH2:19][C:18]1=[O:23]

Participants

4

Reactant 1

HCID 23369980HCID 23369980, compound

Product 1

HCID 21839852[1,4'-Bipiperidin]-2-one

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

2-Oxo-[1,4′]bipiperidinyl-1′-carboxylic acid benzyl ester (2.5 g) and Pearlman's catalyst (0.50 g) was stirred in ethanol (30 mL) under hydrogen (1 atm). After 20 hours the reaction as filtered through celite and concentrated. The title compound was obtained as a white solid (1.45 g). MS: m/z=183 (M+H).

Workup

  1. customAfter 20 hours the reaction
  2. filtrationas filtered through celite and
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-cad510d22ef144e9bbc92fbeab35ec16
Source dataset
uspto-grants-2008_05
Patent number
US07368461B2

Reaction notes

Loading…