HCID 11590769, compound → HCID 58671553, compound

HRID 2221090Notes

Reaction equation

HRID 2221090 reaction equation
[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:15][N:16]=2)[CH2:11][CH:10]([NH:24]C(=O)OCC2C=CC=CC=2)[C:9]1=[O:35])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.CO.[Pd]>[NH2:24][CH:10]1[CH2:11][C:12]2[C:17](=[N:16][CH:15]=[C:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:13]=2)[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9]1=[O:35]

Participants

5

Reactant 1

HCID 11590769HCID 11590769, compound

Product 1

HCID 58671553HCID 58671553, compoundYield 100%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1I (170 mg, 0.367 mmol) in THF (5 mL) and MeOH (5 mL) at RT was added palladium 5% wt. on activated carbon (85 mg). The reaction mixture was stirred under a hydrogen balloon for lh. The reaction was filtered and the filtrate concentrated to give the title compound as a light yellowish oil (120 mg, 100%). LC/MS (method A): retention time=3.07 min, (M+H)+=330.

Workup

  1. filtrationThe reaction was filtered
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-a554853c78e949b4be5233b0b76c4f63
Source dataset
uspto-grants-2008_05
Patent number
US07368458B2

Reaction notes

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