3,5-Dimethylpyrazole → HCID 69218062, compound

HRID 2221369Notes

Reaction equation

HRID 2221369 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1.[N:8]([CH2:11][Si:12]([O:16][CH3:17])([O:14][CH3:15])[CH3:13])=[C:9]=[O:10]>C(OCC)(=O)C>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([C:9](=[O:10])[NH:8][CH2:11][Si:12]([O:16][CH3:17])([O:14][CH3:15])[CH3:13])[N:3]=1

Participants

4

Reactant 2

HCID 62103,5-DimethylpyrazoleHCID 17959832(Isocyanatomethyl)(dimethoxy)methylsilane

Product 1

HCID 69218062HCID 69218062, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A stirred solution conditioned at a temperature of 50° C. of 10.0 g of 3,5-dimethylpyrazole in 80 ml of ethyl acetate was admixed dropwise with 16.8 g of (isocyanatomethyl)dimethoxy(methyl)silane and the clear solution was stirred for 60 min. Distillative removal of the solvent under reduced pressure gave 3,5-dimethyl-1-{[dimethoxy(methyl)silyl]methylcarbamoyl}pyrazole in quantitative yield with a purity of >95% (analysis by 29Si and 1H NMR).

Workup

  1. customDistillative removal of the solvent under reduced pressure

Sources & evidence

ORD record
ord-76bb99742686401589c8eb5317675b2c
Source dataset
uspto-grants-2008_05
Patent number
US07368586B2

Reaction notes

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