反应详情

To a solution of methyl 2-ethyl-5-methyl-1,3-thiazole-4-carboxylate (8.1 g) in tetrahydrofuran (400 mL) was added lithium aluminum hydride (1.8 g) at 0° C., and the mixture was stirred for 2 hrs. Sodium sulfate decahydrate (15.5 g) was added to the reaction mixture, and the mixture was stirred for 1 hr. The reaction mixture was filtered and concentrated. The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (5:95-70:30, v/v) to give (2-ethyl-5-methyl-1,3-thiazol-4-yl)methanol as a yellow oil (3.7 g, yield 53%).

1. stirringthe mixture was stirred for 1 hr
2. filtrationThe reaction mixture was filtered
3. concentrationconcentrated
4. washeluted with ethyl acetate-hexane (5:95-70:30, v/v)