反应详情

温度

90 °C

To a mixture of 4-[(4-chloromethyl-2-methoxyphenoxy)methyl]-2-(2-furyl)-1,3-oxazole (0.80 g), 3-hydroxy-1-phenyl-1H-pyrazole-4-carbaldehyde (0.45 g) and N,N-dimethylformamide (30 mL) was added sodium hydride (60% in oil, 0.10 g) at room temperature, and the mixture was stirred at 90° C. for 2 hrs. Water was added to the reaction mixture, and the precipitated crystals were collected by filtration to give 3-[(4-{[2-(2-furyl)-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-1-phenyl-1H-pyrazole-4-carbaldehyde as pale-yellow crystals (0.93 g, yield 82%). Recrystallization from ethyl acetate-hexane gave pale-yellow prism crystals. melting point: 162-163° C.

1. filtrationthe precipitated crystals were collected by filtration