反应详情

To a mixture of ethyl (2E)-3-[5-({4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenoxy}methyl)-2-phenyl-1,3-oxazol-4-yl]-2-propenoate (0.40 g), tetrahydrofuran (2 mL) and ethanol (2 mL) was added 1N aqueous sodium hydroxide solution (2 mL), and the mixture was heated under reflux for 1 hr. To the reaction mixture were added 1N hydrochloric acid (2 mL) and water, and the precipitated crystals were collected by filtration to give (2E)-3-[5-({4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenoxy}methyl)-2-phenyl-1,3-oxazol-4-yl]-2-propenoic acid as colorless crystals (0.37 g, yield 97%). Recrystallization from tetrahydrofuran-hexane gave colorless prism crystals. melting point: 209-210° C.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hr
3. filtrationthe precipitated crystals were collected by filtration