Hydrochloric Acid → Lithium Chloride

HRID 2222100Notes

Reaction equation

HRID 2222100 reaction equation
C[O:2][C:3]([C:5]1[N:6]([CH3:17])[C:7]([CH2:10][N:11]([CH2:13][CH2:14][O:15][CH3:16])[CH3:12])=[N:8][CH:9]=1)=[O:4].O.O.[OH-].[Li+:21].[ClH:22]>CO>[CH3:16][O:15][CH2:14][CH2:13][N:11]([CH2:10][C:7]1[N:6]([CH3:17])[C:5]([C:3]([OH:4])=[O:2])=[CH:9][N:8]=1)[CH3:12].[Cl-:22].[Li+:21]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 58592596HCID 58592596, compound

Product 2

HCID 433294Lithium ChlorideHCID 58592605HCID 58592605, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-{[(2-Methoxy-ethyl)-methyl-amino]-methyl}-3-methyl-3H-imidazole-4-carboxylic acid methyl ester (380 mg, 1.58 mmol) were dissolved in methanol (4.5 ml) and treated with water (0.39 ml) and lithium hydroxide monohydrate (80 mg, 1.89 mmol) and stirred for 18 h at ambient temperature. The reaction mixture is the carefully acidified at 0° C. with 1N hydrochloric acid and evaporated to dryness. The title compound was obtained as mixture with lithium chloride and used without further purification. Light brown solid (>98% yield by 1H-NMR). MS: m/e=226(M−H+).

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-7d34d71eadac4bd991d2a8bfbd6c8564
Source dataset
uspto-grants-2008_05
Patent number
US07371749B2

Reaction notes

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