HCID 86603475, compound → HCID 11712998, compound

HRID 2222128Notes

Reaction equation

HRID 2222128 reaction equation
[CH2:1]([C@H:3]1[N:12]([CH:13]([CH3:15])[CH3:14])[C:11]2[N:10]=[C:9]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][CH2:31][NH:32]C(=O)OCC5C=CC=CC=5)[CH2:25][CH2:24]4)=[CH:19][C:18]=3[O:43][CH3:44])[N:8]=[CH:7][C:6]=2[N:5]([CH3:45])[C:4]1=[O:46])[CH3:2].[H][H]>CO.[OH-].[Pd+2].[OH-]>[NH2:32][CH2:31][CH2:30][CH2:29][N:26]1[CH2:27][CH2:28][N:23]([C:20]2[CH:21]=[CH:22][C:17]([NH:16][C:9]3[N:8]=[CH:7][C:6]4[N:5]([CH3:45])[C:4](=[O:46])[C@@H:3]([CH2:1][CH3:2])[N:12]([CH:13]([CH3:14])[CH3:15])[C:11]=4[N:10]=3)=[C:18]([O:43][CH3:44])[CH:19]=2)[CH2:24][CH2:25]1

Participants

5

Reactant 2

HCID 86603475HCID 86603475, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 11712998HCID 11712998, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

33 mg (0.045 mmol) benzyl (3-{4-[4-((R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-3-methoxy-phenyl]-piperazin-1-yl}-propyl)-carbamate are taken up in 5 ml of methanol combined with 4 mg palladium hydroxide and stirred for 24 h at 20° C. and 7 bar hydrogen pressure. Then the catalyst is filtered off and the solvent is eliminated in vacuo.

Workup

  1. filtrationThen the catalyst is filtered off

Sources & evidence

ORD record
ord-117ebf5dde2f4cfd8580ccaefe2cde7d
Source dataset
uspto-grants-2008_05
Patent number
US07371753B2

Reaction notes

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