Acetic Acid → HCID 69286939, compound

HRID 2222188Notes

Reaction equation

HRID 2222188 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([N:11]([C:22](=[O:31])[C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=2[Cl:30])[C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)[S:9][CH:10]=1)=[O:5])C.C(O)(=O)C.Cl>O1CCOCC1>[Cl:30][C:24]1[CH:25]=[C:26]([Cl:29])[CH:27]=[CH:28][C:23]=1[C:22]([N:11]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=1)[C:8]1[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=1)=[O:31]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 11190834HCID 11190834, compound

Product 1

HCID 69286939HCID 69286939, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 2.25 g (4.68 mmol) 2-[(2,4-Dichloro-benzoyl)-(3,4-dimethoxy-phenyl)-amino]-thiazole-4-carboxylic acid ethyl ester, 2.5 ml acetic acid and 7.5 ml HCl conc. in 10 ml dioxane was heated to 60° C. for 2 h. The precipitate was filtered off and washed with dioxane to yield after drying 0.566 g (22%) of the title compound. MS (m/e): 453.0 (MH+, 100%)

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with dioxane
  3. customto yield
  4. dry with materialafter drying 0.566 g (22%) of the title compound

Sources & evidence

ORD record
ord-54aca99588114e6c94afc3e89993849b
Source dataset
uspto-grants-2008_05
Patent number
US07371751B2

Reaction notes

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