Triethylamine → HCID 69288119, compound

HRID 2222194Notes

Reaction equation

HRID 2222194 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[S:10][C:11]([CH3:17])=[C:12]([C:14]([OH:16])=[O:15])[N:13]=2)=[CH:4][CH:3]=1.[Cl:18][C:19]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22].CCN(CC)CC>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([C:21](=[O:22])[C:20]2[CH:24]=[CH:25][C:26]([Cl:28])=[CH:27][C:19]=2[Cl:18])[C:9]2[S:10][C:11]([CH3:17])=[C:12]([C:14]([OH:16])=[O:15])[N:13]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 666452,4-Dichlorobenzoyl chlorideHCID 86056602HCID 86056602, compound

Product 1

HCID 69288119HCID 69288119, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 2.0 g (7.4 mmol) 2-(4-Chloro-phenylamino)-5-methyl-thiazole-4-carboxylic acid, 1.56 ml (11.1 mmol) 2,4-Dichlorobenzoyl chloride and 3.09 ml (22.3 mmol) NEt3 in 30 ml DCM was stirred at room temperature for 2 h. After removal of all volatiles the resulting yellow foam was used without further purification in the consecutive step. MS (m/e): 441.0 (MH+, 100%)

Workup

  1. customAfter removal of all volatiles the resulting yellow foam
  2. customwas used without further purification in the consecutive step

Sources & evidence

ORD record
ord-9cdc193e14fc438fb484aecfb7e8a7fa
Source dataset
uspto-grants-2008_05
Patent number
US07371751B2

Reaction notes

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