HCID 69287896, compound → HCID 11203184, compound

HRID 2222213Notes

Reaction equation

HRID 2222213 reaction equation
ClC1C=CC([N:8]([C:18](=O)[C:19]2[CH:24]=[CH:23]C(Cl)=CC=2Cl)C2SC(C)=C(C(O)=O)N=2)=CC=1.[Cl:28][C:29]1[CH:56]=[C:55]([Cl:57])[CH:54]=[CH:53][C:30]=1[C:31]([N:33]([C:43]1[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[C:45]([O:51][CH3:52])[CH:44]=1)[C:34]1[S:35][C:36]([CH3:42])=[C:37]([C:39](O)=[O:40])[N:38]=1)=[O:32]>CCN(CC)CC>[Cl:28][C:29]1[CH:56]=[C:55]([Cl:57])[CH:54]=[CH:53][C:30]=1[C:31]([N:33]([C:43]1[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[C:45]([O:51][CH3:52])[CH:44]=1)[C:34]1[S:35][C:36]([CH3:42])=[C:37]([C:39]([N:8]2[CH2:18][CH2:19][CH2:24][CH2:23]2)=[O:40])[N:38]=1)=[O:32]

Participants

4

Reactant 2

HCID 69287896HCID 69287896, compoundHCID 69288119HCID 69288119, compound

Product 1

HCID 11203184HCID 11203184, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

According to the procedure described fort he synthesis of Example 96 further derivatives have been synthesised from 2-[(4-Chloro-phenyl)-(2,4-dichloro-benzoyl)-amino]-5-methyl-thiazole-4-carboxylic acid or 2-[(2,4-Dichloro-benzoyl)-(3,4-dimethoxy-phenyl)-amino]-5-methyl-thiazole-4-carboxylic acid and various commercially available amines and comprise Examples 97-Example 124 below. In cases of Example 102 and 118 additionally 2 eq. NEt3 were added to the reaction mixture as amine hydrochlorides were used as starting materials.

Workup

  1. customfort he synthesis of Example 96 further derivatives

Sources & evidence

ORD record
ord-cdf7bb7ce9e8496b984e915161f00535
Source dataset
uspto-grants-2008_05
Patent number
US07371751B2

Reaction notes

Loading…