反应详情

温度

50 °C

To a suspension of 2-methylthio-5-(2-hydroxyethyl)-6-methyl-3H-pyrimidin-4-one (34 g, 0.17 mol) in DMF (300 ml) was added slowly one equivalent of sodium hydride (55%, 7.4 g). Next was added slowly one equivalent of methyl iodide (10.5 ml). The mixture was stirred for two hours at 50° C., after which most of the DMF was removed in vaccuum. Water was added and the mixture was extracted with ethyl acetate. The combined organic layer was dried over sodium sulfate and then concentrated and purified by flash chromatografy (eluens: ether followed by ether/methanol=9/1). Yield 20.3 g (56%), mp. 117-118° C.

1. customafter which most of the DMF was removed in vaccuum
2. additionWater was added
3. extractionthe mixture was extracted with ethyl acetate
4. dry with materialThe combined organic layer was dried over sodium sulfate
5. concentrationconcentrated
6. custompurified by flash chromatografy (eluens: ether followed by ether/methanol=9/1)