Hydrochloric Acid → HCID 23089844, compound

HRID 2222380Notes

Reaction equation

HRID 2222380 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4](/[CH:8]=[C:9](/[C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)\[C:10]#[N:11])[CH:5]=[CH:6][CH:7]=1.[ClH:22].O1CCOCC1>C(#N)C>[ClH:22].[NH2:1][C:2]1[CH:3]=[C:4](/[CH:8]=[C:9](/[C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)\[C:10]#[N:11])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 9995865HCID 9995865, compound

Product 1

HCID 23089844HCID 23089844, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Compound 57 (500 mg) was suspended in hydrochloric acid (1.1 eq.), and 1,4-dioxane and acetonitrile were added to and dissolved in the resultant suspension. The resultant reaction mixture was concentrated to dryness under reduced pressure, followed by recrystallization, to thereby produce the target product (550 mg, yield: 97%).

Workup

  1. customThe resultant reaction mixture
  2. concentrationwas concentrated to dryness under reduced pressure
  3. customfollowed by recrystallization

Sources & evidence

ORD record
ord-9ddcb8ed07464fa189b60ffd818a9775
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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