p-Toluenesulfonic acid → HCID 68860790, compound

HRID 2222387Notes

Reaction equation

HRID 2222387 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=[C:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[NH:1]([C:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 6115AnilineHCID 83224Decanoic acid, 3-oxo-, ethyl ester

Product 1

HCID 68860790HCID 68860790, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of aniline (6 mmol), ethyl 3-oxodecanoate (6 mmol) and toluene-p-sulfonic acid (50 mg) in dry toluene (60 ml) was heated under reflux for 24 hours using Dean-Stark apparatus for the azeotropic removal of water. The solvent was removed in vacuum to afford the title product as an oil which was used without purification in the next step.

Workup

  1. temperatureunder reflux for 24 hours
  2. customfor the azeotropic removal of water
  3. customThe solvent was removed in vacuum

Sources & evidence

ORD record
ord-76bd66c184634e898b72634b66da1508
Source dataset
uspto-grants-2008_05
Patent number
US07371779B2

Reaction notes

Loading…