Hydrochloric Acid → 1-(5-chloro-1H-benzimidazol-2-yl)-1-phenyl-methylamine

HRID 2222544Notes

Reaction equation

HRID 2222544 reaction equation
C([NH:4][CH:5]([C:12]1[NH:16][C:15]2[CH:17]=[CH:18][C:19]([Cl:21])=[CH:20][C:14]=2[N:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=O)C.Cl>C(O)C>[Cl:21][C:19]1[CH:18]=[CH:17][C:15]2[NH:16][C:12]([CH:5]([NH2:4])[C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)=[N:13][C:14]=2[CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178474527HCID 178474527, compound

Product 1

HCID 431144671-(5-chloro-1H-benzimidazol-2-yl)-1-phenyl-methylamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1.34 g (4.47 mmol) N-acetyl-1-(5-chloro-1H-benzimidazol-2-yl)-1-phenyl-methylamine in 9 ml of ethanol are combined with 18 ml of conc. hydrochloric acid and heated to 50° C. for 2 days. The reaction mixture is evaporated down i. vac. and twice taken up in ethanol and evaporated down again.

Workup

  1. customThe reaction mixture is evaporated down i
  2. customevaporated down again

Sources & evidence

ORD record
ord-c31caa2950fc40fb86f8658893843333
Source dataset
uspto-grants-2008_05
Patent number
US07371743B2

Reaction notes

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