Hydrochloric Acid → N,3-Dihydroxypyridine-4-carboxamide

To a stirred suspension of methyl 3-hydroxy-isonicotinate (176 g; 1.15 mol) in water/ice (50/50, 1700 mL), was added hydroxylamine hydrochloride (127.9 g; 1.84 mol). The temperature fell to −5° C. and then aqueous NaOH solution (454 mL, 28% w/v) was added dropwise keeping the temperature below 5° C. during the addition. Hereafter the reaction mixture was stirred at ambient temperature for 1.5 h followed by heating to 60° C. At this temperature the pH was adjusted to 5.4 by the addition of aqueous hydrochloric acid (10 M) at which point a heavy precipitate forms. The reaction mixture was then stirred at ambient temperature followed by cooling to 5° C. The pH was then adjusted to 4.0 by the addition of aqueous hydrochloric acid (10 M), and then was stirred whilst cold for 1.5 h. The crystals were filtered off, rinsed with water (3×100 mL), dried on the filter and then dried further at reduced pressure and 40° C. overnight to give 3,N-dihydroxy-isonicotinamide (169.3 g, 96%; HPLC purity 98%) as a white solid.

1. customfell to −5° C.
2. customthe temperature below 5° C.
3. additionduring the addition
4. temperatureby heating to 60° C
5. stirringThe reaction mixture was then stirred at ambient temperature
6. temperatureby cooling to 5° C
7. stirringwas stirred whilst cold for 1.5 h
8. filtrationThe crystals were filtered off
9. washrinsed with water (3×100 mL)
10. customdried on the
11. filtrationfilter
12. customdried further at reduced pressure and 40° C. overnight

ORD record

ord-0f18a5f623304a5c82ad161bb29e7190

Source dataset

uspto-grants-2008_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07371863B2