反应详情

Dimethylformamide (DMF, 20 mL) was added with ethyl 7-bromoheptanoate (4.7 g) and 2,4,6-triiodophenol (2.4 g), further added with potassium carbonate (2.1 g) and stirred at room temperature for one day. The reaction solution was added with water and extracted twice with ethyl acetate, and the organic layer was washed three times with water and dried over anhydrous magnesium sulfate. Then, the solvent was removed, and the resulting residue was purified by silica gel column chromatography to obtain ethyl 7-(2,4,6-triiodophenoxy)heptanoate (6.0 g, yield: 96%).

1. extractionextracted twice with ethyl acetate
2. washthe organic layer was washed three times with water
3. dry with materialdried over anhydrous magnesium sulfate
4. customThen, the solvent was removed
5. customthe resulting residue was purified by silica gel column chromatography