Triethylamine → HCID 86606020, compound

HRID 2222875Notes

Reaction equation

HRID 2222875 reaction equation
C(N(CC)CC)C.[OH:8][C@@H:9]([CH2:31][CH2:32][CH3:33])[CH:10]([C:21]([O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22])[C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12].[CH3:34][S:35](Cl)(=[O:37])=[O:36]>ClCCl>[CH3:34][S:35]([O:8][C@@H:9]([CH2:31][CH2:32][CH3:33])[CH:10]([C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[C:21]([O:23][CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:22])(=[O:37])=[O:36]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 86606021HCID 86606021, compound

Product 1

HCID 86606020HCID 86606020, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

500 ml of triethylamine are added to a solution of 236.9 g of 1 in 1.2 l of dichloromethane. With ice cooling, a solution of 83.6 ml of methanesulfonyl chloride in 200 ml of dichloromethane is added. The mixture is stirred at 5-100 for 30 minutes, the precipitated triethylamine hydrochloride is removed, and the product is subjected to conventional work-up, giving 2 as oil.

Workup

  1. customthe precipitated triethylamine hydrochloride is removed

Sources & evidence

ORD record
ord-64b9b8c154eb46c386498122609c66ce
Source dataset
uspto-grants-2008_05
Patent number
US07371854B2

Reaction notes

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