反应详情

D4 (70 mg, 0.20 mmol), C3 (37 mg, 0.20 mmol), and potassium carbonate (30 mg, 0.22 mmol) were stirred in dimethylformamide at room temperature overnight. The reaction mixture was partitioned between 4:1 ether:dichloromethane and water. The organic layer was washed with water and brine. It was dried over magnesium sulfate, filtered, then concentrated in vacuo. Purified by chromatography (2% to 5% methanol with 0.1% ammonium hydroxide in dichloromethane), yielding 55 mg of D5.

1. customThe reaction mixture was partitioned between 4:1 ether
2. washThe organic layer was washed with water and brine
3. dry with materialIt was dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customPurified by chromatography (2% to 5% methanol with 0.1% ammonium hydroxide in dichloromethane)