Hydrochloric Acid → 2-(4-Fluorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

HRID 2223492Notes

Reaction equation

HRID 2223492 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH2:11][CH2:12][CH:13](C(=O)C)[NH:14][C:15]=3[N:16]=2)=[CH:4][CH:3]=1.Cl>ClCCl.CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH2:15][NH:14][CH2:13][CH2:12][C:11]=3[N:16]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68527358HCID 68527358, compound

Product 1

HCID 625480842-(4-Fluorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared in analogy to example E (b) from 1-[2-(4-fluoro-phenyl)-6,7-dihydro-4H-thiazolo[5,4]pyridin-5-yl]-ethanone and hydrochloric acid. Chromatography (SiO2; dichloromethane/methanol 95:5) yields the title compound as a yellowish solid. MS (m/e): 235.1 (M+H+).

Sources & evidence

ORD record
ord-c3d4a9a011834b56a10f2831d07f3dec
Source dataset
uspto-grants-2008_05
Patent number
US07375226B2

Reaction notes

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