Hydrochloric Acid → HCID 59715913, compound

HRID 2223728Notes

Reaction equation

HRID 2223728 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][CH:31]=1)[CH:5]=[C:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][NH:14][C:15]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[N:21]=[C:20]([CH3:28])[CH:19]=2)=[O:16])[CH2:8][CH2:7]1.Cl>CO.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][CH:31]=1)[CH2:5][CH:6]1[CH2:7][CH2:8][N:9]([CH2:12][CH2:13][NH:14][C:15]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[N:21]=[C:20]([CH3:28])[CH:19]=2)=[O:16])[CH2:10][CH2:11]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59715933HCID 59715933, compound

Product 1

HCID 59715913HCID 59715913, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 1-{2-[4-(3-methyl-benzylidene)-piperidin-1-yl]-ethyl}-3-(2-methyl-quinolin-4-yl)-urea (21 mg, 0.05 mmol), 2M aqueous HCl (0.5 mL, 1 mmol) and Pd—C (10%, 5 mg) in MeOH (2 mL) is stirred under hydrogen atmosphere for 6 h. The catalyst is filtered off and the filtrate evaporated to provide the title compound as hydrochloride salt.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-a9e1c22a8de641168f12936e74df0aa9
Source dataset
uspto-grants-2008_05
Patent number
US07375227B2

Reaction notes

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