1-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid ethyl ester → 1-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid

HRID 2223737Notes

Reaction equation

C([O:3][C:4]([C:6]1([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][NH2:14])[CH2:8][CH2:7]1)=[O:5])C>Cl>[NH2:14][CH2:13][CH2:12][N:9]1[CH2:10][CH2:11][C:6]([CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]1

Participants

Conditions

Temperature: 90 °C

Procedure

1-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid ethyl ester (2.5 g, 10 mmol) is dissolved in 6N aqueous HCl (40 mL) and the mixture heated at 90° C. for 96 h. The reaction mixture is evaporated to provide the title compound as hydrochloride salt.

Workup

customThe reaction mixture is evaporated

Sources & evidence

ORD record: ord-d2c8692158c64358a6ab7f4131cc321b
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07375227B2

Reaction notes

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