Phenylboronic Acid → HCID 69289265, compound

HRID 2224320Notes

Reaction equation

HRID 2224320 reaction equation
[C:1]1(B(O)O)C=CC=CC=1.[C:10]([N:13]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=[CH:17][C:16]2[N:25]=[C:26]([C:30]3[CH:31]=N[C:33](OC)=[CH:34][CH:35]=3)[C:27](F)=[CH:28][C:15]=2[CH2:14]1)(=[O:12])[CH3:11]>>[C:10]([N:13]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=[CH:17][C:16]2[N:25]=[C:26]([C:30]3[CH:31]=[CH:1][CH:33]=[CH:34][CH:35]=3)[CH:27]=[CH:28][C:15]=2[CH2:14]1)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 692911976-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocine

Product 1

HCID 69289265HCID 69289265, compoundYield 87%

Procedure

The title compound (19.9 mg, 87%) was prepared from 13C (20.0 mg, 0.07 mmol) and phenylboronic acid (12.8 mg, 0.105 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.353 min; LCMS Found: (M+H)+=327.

Sources & evidence

ORD record
ord-834d9c17a9734d5a8695cdd8a2268ea2
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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