Phenylboronic Acid → HCID 69292204, compound

HRID 2224355Notes

Reaction equation

HRID 2224355 reaction equation
Cl[C:2]1[CH:20]=[CH:19][C:5]2[CH:6]=[CH:7][C:8]3[CH:18]=[CH:17][CH:16]=[CH:15][C:9]=3[N:10]([C:12](=[O:14])[CH3:13])[CH2:11][C:4]=2[N:3]=1.[C:21]1(B(O)O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(N1C2C=CC=CC=2C=CC2N=C(C3C=NC(OC)=CC=3)C(F)=CC=2C1)(=O)C>>[C:12]([N:10]1[C:9]2[CH:15]=[CH:16][CH:17]=[CH:18][C:8]=2[CH:7]=[CH:6][C:5]2[CH:19]=[CH:20][C:2]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[N:3][C:4]=2[CH2:11]1)(=[O:14])[CH3:13]

Participants

4

Reactant 3

HCID 66827Phenylboronic AcidHCID 692911976-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocineHCID 723667791-(2-chloro-12H-1,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanone

Product 1

HCID 69292204HCID 69292204, compoundYield 102.1%

Procedure

Compound 55D (6.0 mg, 100%) was prepared from 55C (5.0 mg, 0.018 mmol) and phenylboronic acid (2.2 mg, 0.018 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.729 min; LCMS Found: (M+H)+=327.

Sources & evidence

ORD record
ord-6653363787fd419f82744ca3a74752c5
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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