反应详情

To a solution of 2-hydroxy-5-methoxybenzaldehyde (4.00 g) in formic acid (30 ml) were added hydroxylamine hydrochloride (2.01 g) and sodium formate (3.22 g) at room temperature and the mixture was refluxed for 2 hours. The reaction mixture was concentrated. the residue was diluted with water and was extracted with t-butyl methyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated. The residue was washed with a mixture of t-butyl methyl ether and hexane to give the title compound (2.02 g) having the following physical data.

1. temperaturethe mixture was refluxed for 2 hours
2. concentrationThe reaction mixture was concentrated
3. additionthe residue was diluted with water
4. extractionwas extracted with t-butyl methyl ether
5. washThe extract was washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated
8. washThe residue was washed with a mixture of t-butyl methyl ether and hexane