Ammonia → HCID 11235514, compound

HRID 2225021Notes

Reaction equation

HRID 2225021 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:21][C:20]([CH2:22][O:23][C:24](=[O:30])[CH2:25][CH2:26][C:27]([OH:29])=[O:28])=[CH:19][CH:18]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N>C1COCC1>[NH4+:8].[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:21][C:20]([CH2:22][O:23][C:24](=[O:30])[CH2:25][CH2:26][C:27]([O-:29])=[O:28])=[CH:19][CH:18]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 10222876HCID 10222876, compound

Product 1

HCID 11235514HCID 11235514, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 1 (170 mg, 0.4 mmle) in 10 mL THF was treated with NH3 at 25° C. After 30 mins, the precipitate formed in the reaction was filtered out to give Compound 17 in a yield of 90%.

Workup

  1. customthe precipitate formed in the reaction
  2. filtrationwas filtered out

Sources & evidence

ORD record
ord-ec8ea9d276a146b28de6c1c57951643a
Source dataset
uspto-grants-2008_05
Patent number
US07378532B2

Reaction notes

Loading…