Water → HCID 59449243, compound

HRID 222526Notes

Reaction equation

HRID 222526 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].C(O[C:12](=O)[NH:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH:16]([N:20]2[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]2)[CH2:15]1)(C)(C)C.[OH-].[Na+].O>C1(C)C=CC=CC=1.C1COCC1>[CH3:12][NH:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH:16]([N:20]2[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]2)[CH2:15]1

Participants

7

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 58393283HCID 58393283, compound

Product 1

HCID 59449243HCID 59449243, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
75 °C

Procedure

8.57 ml (8.57 mmol) of a 1 M solution of lithium aluminium hydride in toluene were dissolved in 8 ml THF and at ambient temperature slowly combined with 850 mg (2.86 mmol) of product from Example 4 (J) dissolved in 2 ml THF. The reaction solution was stirred for 2 hours at 75° C. Then 1N sodium hydroxide solution and water were added.

Sources & evidence

ORD record
ord-a49e6f98a0c94124b717b718c9d9f968
Source dataset
uspto-grants-2012_06
Patent number
US08207335B2

Reaction notes

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