反应详情

A mixture of 4-(diphenylmethoxymethyl)piperidine (1.40 g, 5.0 mmol--see Preparation 2), 3-methoxyphenethyl bromide (1.08 g, 5.0 mmol), sodium carbonate (1.06 g) and sodium iodide (0.50 g) in acetonitrile (30 ml) was heated under reflux for 16 hours, diluted with ethyl acetate and water and the layers separated. The organic layer was washed with water, dried over magnesium sulphate and evaporated. The residue was purified by chromatography on silica using dichloromethane plus 0-5% methanol as eluant. Appropriate fractions were combined and evaporated to give the title compound (1.12 g) as a colourless oil.

1. temperaturewas heated
2. temperatureunder reflux for 16 hours
3. customthe layers separated
4. washThe organic layer was washed with water
5. dry with materialdried over magnesium sulphate
6. customevaporated
7. customThe residue was purified by chromatography on silica
8. customevaporated