反应详情

5 g of potassium carbonate was added to a solution of 1.6 g of allyl cis-4-(4-acetoxy-3-methoxycinnamoyloxy )-1-methyl-1-cyclohexanecarboxylate (Example 9) in 80 ml of methanol. The resultant solution was stirred for 2 hours at room temperature. After reaction, 2N hydrochloric acid was added to the reaction solution, acidifying the solution. The solution was extracted three times with 50 ml of ethyl acetate. The organic layer obtained was washed once with an aqueous sodium hydrogencarbonate solution and once with an aqueous sodium chloride solution, and was then dried over magnesium sulfate. The solvent was removed in vacuo, yielding 0.62 g of allyl cis-4--(4-hydroxy-3-methoxycinnamoyloxy)-1-methyl-1cyclohexanecarboxylate (a compound of the present invention) as white crystal, which had the following physiochemical properties:

1. additionwas added to the reaction solution
2. extractionThe solution was extracted three times with 50 ml of ethyl acetate
3. customThe organic layer obtained
4. washwas washed once with an aqueous sodium hydrogencarbonate solution and once with an aqueous sodium chloride solution
5. dry with materialwas then dried over magnesium sulfate
6. customThe solvent was removed in vacuo