4-Methylpiperidine → 1-(4-Acetoxy-3-methoxycinnamoyl)-4-methylpiperidine

HRID 2225506Notes

Reaction equation

HRID 2225506 reaction equation
[C:1]([O:4][C:5]1[CH:15]=[CH:14][C:8]([CH:9]=[CH:10][C:11](Cl)=[O:12])=[CH:7][C:6]=1[O:16][CH3:17])(=[O:3])[CH3:2].[CH3:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>N1C=CC=CC=1>[C:1]([O:4][C:5]1[CH:15]=[CH:14][C:8]([CH:9]=[CH:10][C:11]([N:22]2[CH2:23][CH2:24][CH:19]([CH3:18])[CH2:20][CH2:21]2)=[O:12])=[CH:7][C:6]=1[O:16][CH3:17])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 693814-MethylpiperidineHCID 544680224-Acetoxy-3-methoxycinnamoyl chloride

Product 1

HCID 541364281-(4-Acetoxy-3-methoxycinnamoyl)-4-methylpiperidine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Using 5.09 g of 4-acetoxy-3-methoxycinnamoyl chloride, 2.4 ml of 4-methylpiperidine, and 100 ml of pyridine, a reaction similar to that conducted in Example 53 was carried out. As a result, 5.2 g of 1-(4-acetoxy-3-methoxycinnamoyl)-4-methylpiperidine (a compound of the present invention) was obtained as an orange-yellow oil, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-9b3a5e860ace429da7458b6edcfc51f4
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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