Potassium Carbonate → N-cyclohexyl-4-hydroxy-3-methoxycinnamamide

HRID 2225509Notes

Reaction equation

HRID 2225509 reaction equation
[CH:1]1([NH:7][C:8](=[O:23])[CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17]C(=O)C)=[C:13]([O:21][CH3:22])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1]1([NH:7][C:8](=[O:23])[CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:21][CH3:22])[CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 54552956N-cyclohexyl-4-acetoxy-3-methoxycinnamamide

Product 1

HCID 54188453N-cyclohexyl-4-hydroxy-3-methoxycinnamamideYield 101.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using 2.64 g of N-cyclohexyl-4-acetoxy-3-methoxycinnamamide (Example 57), 70 ml of methanol, and 5 g of potassium carbonate, a reaction similar to that conducted in Example 54 was carried out. As a result, 2.32 g of N-cyclohexyl-4-hydroxy-3-methoxycinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-244ac2bbda19482ab19c178ce3ac3724
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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