1-Methylpiperazine → HCID 178490543, compound

HRID 2225571Notes

Reaction equation

[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:24])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20]Cl)=[C:14]([O:22][CH3:23])[CH:13]=2)[CH2:4][CH2:3]1.[CH3:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:24])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:29]3[CH2:30][CH2:31][N:26]([CH3:25])[CH2:27][CH2:28]3)=[C:14]([O:22][CH3:23])[CH:13]=2)[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 178490530HCID 178490530, compound

Product 1

HCID 178490543HCID 178490543, compound

Procedure

Using 3.9 g of N-(trans-4-methylcyclohexyl)-4-(2-chloroethoxy)-3-methoxycinnamamide (Example 138) and 24 ml of 1-methylpiperazine, a reaction similar to that conducted in Example 142 was carried out. As a result, 2.24 g of N-(trans-4-methylcyclohexyl)-4-[2-(4-methylpiperazinyl)ethoxy]-3-methoxycinnamamide (a compound of the present invention) was obtained as light-brownish white crystal, which had the following physioche mical properties:

Workup

customa reaction similar to

Sources & evidence

ORD record: ord-abcaf479929442bb82b48ade1e9cb8d1
Source dataset: uspto-grants-1994_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05344845

Reaction notes

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