反应详情

To a mixture of 130 mg (0.19 mmole) of 4-(N,N-di-n-pentylcarbamoyl)-1-(N,N-diphenylcarbamoyl)-2-(2-(N-methyl-N-(t-butoxycarbonyl)amino)-N-(methyl)ethylaminocarbonyl)piperazine and 0.4 mL of anisole at 0° C. was added 2 mL of trifluoroacetic acid precooled to 0° C. After 45 min the solution was concentrated in vacuo and the residue purified by flash chromatography on 16 g of silica gel eluting with 100:9 CH2Cl2 :MeOH to give 130 mg (98%) of an oil.

1. customprecooled to 0° C
2. concentrationAfter 45 min the solution was concentrated in vacuo
3. customthe residue purified by flash chromatography on 16 g of silica gel eluting with 100:9 CH2Cl2