Hydrochloric Acid → GK-128

HRID 2226251Notes

Reaction equation

HRID 2226251 reaction equation
[CH3:1][C:2]1[N:3]([CH2:7][C:8]2[C:9](=[O:22])[C:10]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=[CH:14][C:11]=3[S:12][CH:13]=2)[CH:4]=[CH:5][N:6]=1.[ClH:23]>CO>[ClH:23].[CH3:1][C:2]1[N:3]([CH2:7][C:8]2[C:9](=[O:22])[C:10]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=[CH:14][C:11]=3[S:12][CH:13]=2)[CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 178064HCID 178064, compound

Product 1

HCID 178063GK-128

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.1 g of 2-[(2-methyl-1-imidazolyl)methyl]- 1H-naphtho[2,1-b]thiopyran-1-one obtained in Example 3, after dissolving in methanol, was converted into the hydrochloride with conc. hydrochloric acid. After evaporation of the solvent under reduced pressure, the residue was recrystallized from methanol - diethyl ether to give 64 mg of the title compound.

Workup

  1. customAfter evaporation of the solvent under reduced pressure
  2. customthe residue was recrystallized from methanol - diethyl ether

Sources & evidence

ORD record
ord-746eddc3cce546cfae4ca95ab326d4f5
Source dataset
uspto-grants-1994_09
Patent number
US05347012

Reaction notes

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