反应详情

温度

100 °C

2-Aminoimidazole monosulfate (500 mg, 1.89 mmol) and potassium carbonate (580 mg, 4.16 mmol) were suspended in DMF (2 mL) and chloroethyl piperidine mono hydrochloride (766 mg, 4.16 mmol) was added. The reaction was heated at 100° C. for 2.5 hours before being cooled to room temperature and filtered. The filtrate was concentrated and purified by column chromatography (95:4.5:0.5 dichloromethane:methanol:aqueous ammonia) and the product was isolated as a brown oil (83 mg, 11%).

1. temperaturebefore being cooled to room temperature
2. filtrationfiltered
3. concentrationThe filtrate was concentrated
4. custompurified by column chromatography (95:4.5:0.5 dichloromethane:methanol:aqueous ammonia)