HCID 53783517, compound → HCID 18964404, compound

HRID 2226347Notes

Reaction equation

HRID 2226347 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]([C:14]2[CH:31]=[CH:30][C:17]([CH:18]=[CH:19][C:20]([O:22][CH2:23][C:24]([F:29])([F:28])[CH:25]([F:27])[F:26])=[O:21])=[CH:16][CH:15]=2)=[N:12][CH:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]>C1COCC1.[Pd]>[CH2:1]([C:8]1[CH:13]=[N:12][C:11]([C:14]2[CH:31]=[CH:30][C:17]([CH2:18][CH2:19][C:20]([O:22][CH2:23][C:24]([F:28])([F:29])[CH:25]([F:26])[F:27])=[O:21])=[CH:16][CH:15]=2)=[N:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

4

Reactant 1

HCID 53783517HCID 53783517, compound

Product 1

HCID 18964404HCID 18964404, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

0.01 mol of 2,2,3,3-tetrafluoropropyl p-(5-heptyl-pyrimidin-2-yl)-cinnamate (for preparation see Example 21) are hydrogenated in THF with Pd/C in the known manner. Usual working-up gives 2,2,3,3-tetrafluoropropyl β-[p-(5-heptyl-pyrimidin-2-yl)-phenyl]-propionate of m.p. 42° and c.p. 54°.

Sources & evidence

ORD record
ord-e1de1d26b85a41a2a7182354596ca6b2
Source dataset
uspto-grants-1994_09
Patent number
US05348677

Reaction notes

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